[Immunogenicity of attenuated reassortants of influenza A virus /Leningrad/134/47/57 (H2N2) for mice, depending on their genome].
Identifieur interne : 002E12 ( Main/Exploration ); précédent : 002E11; suivant : 002E13[Immunogenicity of attenuated reassortants of influenza A virus /Leningrad/134/47/57 (H2N2) for mice, depending on their genome].
Auteurs : A Iu Egorov ; L M Garmashova ; G N Nevedomskaia ; L I Bogomolova ; A M Kha Der ; G I AleksandrovaSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Animaux, Basse température, Génome viral, Phénotype, Poumon (virologie), Réplication virale, Souris, Souris de lignée CBA, Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux (immunologie), Vaccins atténués (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (physiologie).
- MESH :
- génétique : Virus de la grippe A.
- immunologie : Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
- physiologie : Virus de la grippe A.
- virologie : Poumon.
- Animaux, Basse température, Génome viral, Phénotype, Réplication virale, Souris, Souris de lignée CBA, Sous-type H2N2 du virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Cold Temperature, Genome, Viral, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (physiology), Influenza Vaccines (immunology), Lung (virology), Mice, Mice, Inbred CBA, Phenotype, Vaccines, Attenuated (immunology), Virus Replication.
- MESH :
- chemical , immunology : Influenza Vaccines, Vaccines, Attenuated.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- physiology : Influenza A virus.
- virology : Lung.
- Animals, Cold Temperature, Genome, Viral, Influenza A Virus, H2N2 Subtype, Mice, Mice, Inbred CBA, Phenotype, Virus Replication.
Abstract
Reassortants of cold-adapted strain A/Leningrad/134/47/57 (H2N2) and virulent strain A/PR/8/34 (H1N1), modeling genomic composition of vaccinal strains, were tried in mouse experiments. Reassortants' genomes included the major part (5, 6, or 7) from cold-adapted strain and 1 to 3 genes of virulent strain. All the tested reassortants did not differ by temperature sensitivity or cold adaptation phenotypes, did not cause the death of mice, but differed by the level of reproduction in murine lungs and by immunogenicity. Strains with genomic formulas 6/2 (HA and NA of a virulent strain) and 5/3 (M) (HA, NA, and M of a virulent strain) were characterized by the highest immunogenicity. Reassortants including, besides HA and NA, PA gene 5/3 (PA) or inheriting only HA gene from strain A/pr/8/34 (H1N1) were hyperattenuated and low immunogenic.
PubMed: 7716900
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000414
- to stream PubMed, to step Curation: 000414
- to stream PubMed, to step Checkpoint: 000618
- to stream Ncbi, to step Merge: 001293
- to stream Ncbi, to step Curation: 001293
- to stream Ncbi, to step Checkpoint: 001293
- to stream Main, to step Merge: 002F87
- to stream Main, to step Curation: 002E12
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Immunogenicity of attenuated reassortants of influenza A virus /Leningrad/134/47/57 (H2N2) for mice, depending on their genome].</title><author><name sortKey="Egorov, A Iu" sort="Egorov, A Iu" uniqKey="Egorov A" first="A Iu" last="Egorov">A Iu Egorov</name></author><author><name sortKey="Garmashova, L M" sort="Garmashova, L M" uniqKey="Garmashova L" first="L M" last="Garmashova">L M Garmashova</name></author><author><name sortKey="Nevedomskaia, G N" sort="Nevedomskaia, G N" uniqKey="Nevedomskaia G" first="G N" last="Nevedomskaia">G N Nevedomskaia</name></author><author><name sortKey="Bogomolova, L I" sort="Bogomolova, L I" uniqKey="Bogomolova L" first="L I" last="Bogomolova">L I Bogomolova</name></author><author><name sortKey="Kha Der, A M" sort="Kha Der, A M" uniqKey="Kha Der A" first="A M" last="Kha Der">A M Kha Der</name></author><author><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1994 Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:7716900</idno><idno type="pmid">7716900</idno><idno type="wicri:Area/PubMed/Corpus">000414</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000414</idno><idno type="wicri:Area/PubMed/Curation">000414</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000414</idno><idno type="wicri:Area/PubMed/Checkpoint">000618</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000618</idno><idno type="wicri:Area/Ncbi/Merge">001293</idno><idno type="wicri:Area/Ncbi/Curation">001293</idno><idno type="wicri:Area/Ncbi/Checkpoint">001293</idno><idno type="wicri:doubleKey">0507-4088::Egorov A:immunogenicity:of:attenuated</idno><idno type="wicri:Area/Main/Merge">002F87</idno><idno type="wicri:Area/Main/Curation">002E12</idno><idno type="wicri:Area/Main/Exploration">002E12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Immunogenicity of attenuated reassortants of influenza A virus /Leningrad/134/47/57 (H2N2) for mice, depending on their genome].</title><author><name sortKey="Egorov, A Iu" sort="Egorov, A Iu" uniqKey="Egorov A" first="A Iu" last="Egorov">A Iu Egorov</name></author><author><name sortKey="Garmashova, L M" sort="Garmashova, L M" uniqKey="Garmashova L" first="L M" last="Garmashova">L M Garmashova</name></author><author><name sortKey="Nevedomskaia, G N" sort="Nevedomskaia, G N" uniqKey="Nevedomskaia G" first="G N" last="Nevedomskaia">G N Nevedomskaia</name></author><author><name sortKey="Bogomolova, L I" sort="Bogomolova, L I" uniqKey="Bogomolova L" first="L I" last="Bogomolova">L I Bogomolova</name></author><author><name sortKey="Kha Der, A M" sort="Kha Der, A M" uniqKey="Kha Der A" first="A M" last="Kha Der">A M Kha Der</name></author><author><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cold Temperature</term><term>Genome, Viral</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (physiology)</term><term>Influenza Vaccines (immunology)</term><term>Lung (virology)</term><term>Mice</term><term>Mice, Inbred CBA</term><term>Phenotype</term><term>Vaccines, Attenuated (immunology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Basse température</term><term>Génome viral</term><term>Phénotype</term><term>Poumon (virologie)</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée CBA</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cold Temperature</term><term>Genome, Viral</term><term>Influenza A Virus, H2N2 Subtype</term><term>Mice</term><term>Mice, Inbred CBA</term><term>Phenotype</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Basse température</term><term>Génome viral</term><term>Phénotype</term><term>Réplication virale</term><term>Souris</term><term>Souris de lignée CBA</term><term>Sous-type H2N2 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reassortants of cold-adapted strain A/Leningrad/134/47/57 (H2N2) and virulent strain A/PR/8/34 (H1N1), modeling genomic composition of vaccinal strains, were tried in mouse experiments. Reassortants' genomes included the major part (5, 6, or 7) from cold-adapted strain and 1 to 3 genes of virulent strain. All the tested reassortants did not differ by temperature sensitivity or cold adaptation phenotypes, did not cause the death of mice, but differed by the level of reproduction in murine lungs and by immunogenicity. Strains with genomic formulas 6/2 (HA and NA of a virulent strain) and 5/3 (M) (HA, NA, and M of a virulent strain) were characterized by the highest immunogenicity. Reassortants including, besides HA and NA, PA gene 5/3 (PA) or inheriting only HA gene from strain A/pr/8/34 (H1N1) were hyperattenuated and low immunogenic.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name><name sortKey="Bogomolova, L I" sort="Bogomolova, L I" uniqKey="Bogomolova L" first="L I" last="Bogomolova">L I Bogomolova</name><name sortKey="Egorov, A Iu" sort="Egorov, A Iu" uniqKey="Egorov A" first="A Iu" last="Egorov">A Iu Egorov</name><name sortKey="Garmashova, L M" sort="Garmashova, L M" uniqKey="Garmashova L" first="L M" last="Garmashova">L M Garmashova</name><name sortKey="Kha Der, A M" sort="Kha Der, A M" uniqKey="Kha Der A" first="A M" last="Kha Der">A M Kha Der</name><name sortKey="Nevedomskaia, G N" sort="Nevedomskaia, G N" uniqKey="Nevedomskaia G" first="G N" last="Nevedomskaia">G N Nevedomskaia</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E12 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002E12 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:7716900
|texte= [Immunogenicity of attenuated reassortants of influenza A virus /Leningrad/134/47/57 (H2N2) for mice, depending on their genome].
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:7716900" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |